Department of Biochemistry, Lucknow University, Lucknow, India.
Oxid Med Cell Longev. 2009 Apr-Jun;2(2):68-72. doi: 10.4161/oxim.2.2.8160.
Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols, ascorbic acid and malondialdehyde (MDA) has been done in head and neck squamous cell carcinoma patients before the start of any oncological treatment and compared with healthy controls. The specific activity of superoxide dismutase in cancer patients is decreased significantly when compared to the control (p < 0.05). The total thiol and ascorbic acid levels are significantly reduced (p < 0.005) whereas MDA levels are significantly increased in the patients (p < 0.00005). Our findings show that the oxidative stress is elevated in cancer patients as evidenced by elevated levels of lipid peroxidation products and depletion of enzymatic and non-enzymatic antioxidants.
氧化应激是活性氧的形成和失活之间失衡的结果，可能与包括癌症在内的许多疾病的发病机制有关。为了评估氧化应激的程度，对头颈部鳞状细胞癌患者在开始任何肿瘤治疗前进行了血浆中超氧化物歧化酶、总巯基、抗坏血酸和丙二醛 (MDA) 水平的研究，并与健康对照组进行了比较。与对照组相比，癌症患者的超氧化物歧化酶比活性显著降低 (p<0.05)。总巯基和抗坏血酸水平显著降低 (p<0.005)，而 MDA 水平在患者中显著升高 (p<0.00005)。我们的研究结果表明，癌症患者的氧化应激水平升高，表现为脂质过氧化产物水平升高和酶和非酶抗氧化剂耗竭。
