用抗去唾液酸GM-1抗体处理的严重联合免疫缺陷小鼠中HTLV-I转化的人T细胞（MT-2）的成功移植。
Successful graft of HTLV-I-transformed human T-cells (MT-2) in severe combined immunodeficiency mice treated with anti-asialo GM-1 antibody.
作者信息
Ishihara S, Tachibana N, Okayama A, Murai K, Tsuda K, Mueller N
机构信息
Second Department of Medicine, Miyazaki Medical College, Japan.
出版信息
Jpn J Cancer Res. 1992 Apr;83(4):320-3. doi: 10.1111/j.1349-7006.1992.tb00108.x.
Abstract
To develop an experimental model of adult T-cell leukemia/lymphoma in small animals, severe combined immunodeficiency (SCID) mice treated with anti-asialo GM-1 antibody were inoculated with MT-2 cells, a cell line transformed by the human T-cell leukemia virus (HTLV-I). Three mice injected with 4 x 10(7) cells subcutaneously or intramuscularly developed tumors at or near inoculation sites. Immunofluorescent antibody (IFA) staining for HTLV-I structural protein, p19, revealed the specific antigen in the cytoplasm of most cells from tumors and the DNA signals of HTLV-I proviral DNA were also positive in cellular DNA by polymerase chain reaction assay with HTLV-I tax gene primers, SK43/SK44. The MT-2 cells did not invade in mouse organs.
摘要
为了在小动物中建立成人T细胞白血病/淋巴瘤的实验模型，用抗去唾液酸GM-1抗体处理的严重联合免疫缺陷（SCID）小鼠接种了MT-2细胞，该细胞系由人类T细胞白血病病毒（HTLV-I）转化而来。三只皮下或肌肉注射4×10⁷个细胞的小鼠在接种部位或其附近出现了肿瘤。用免疫荧光抗体（IFA）对HTLV-I结构蛋白p19进行染色，发现肿瘤中大多数细胞的细胞质中有特异性抗原，并且通过使用HTLV-I tax基因引物SK43/SK44进行聚合酶链反应分析，HTLV-I前病毒DNA的DNA信号在细胞DNA中也呈阳性。MT-2细胞未侵袭小鼠器官。
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