新型碳青霉烯类抗生素的体外活性：与美罗培南、L-627和亚胺培南针对致病性诺卡氏菌属的比较研究
In-vitro activity of new carbapenem antibiotics: comparative studies with meropenem, L-627 and imipenem against pathogenic Nocardia spp.
作者信息
Yazawa K, Mikami Y, Ohashi S, Miyaji M, Ichihara Y, Nishimura C
机构信息
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
出版信息
J Antimicrob Chemother. 1992 Feb;29(2):169-72. doi: 10.1093/jac/29.2.169.
MICs of two new carbapenems, meropenem and L-627, and imipenem were determined against 98 strains of the Nocardia asteroides group (i.e. N. asteroides sensu stricto, Nocardia farcinica and Nocardia nova), 46 strains of Nocardia brasiliensis and 17 strains of Nocardia otitidiscaviarum. Meropenem and L-627 were less active against the N. asteroides group than imipenem. Among the three species of the N. asteroides group, N. nova was the most sensitive to all the carbapenems. Meropenem was more active than imipenem against both N. brasiliensis and N. otitidiscaviarum with MIC50 values of 28.3-53.3 mg/L. L-627 was less active than meropenem.
测定了两种新型碳青霉烯类药物美罗培南和L-627以及亚胺培南对98株星形诺卡菌属（即狭义星形诺卡菌、巴西诺卡菌和新星诺卡菌）、46株巴西诺卡菌和17株豚鼠耳炎诺卡菌的最低抑菌浓度（MIC）。美罗培南和L-627对星形诺卡菌属的活性低于亚胺培南。在星形诺卡菌属的三个菌种中，新星诺卡菌对所有碳青霉烯类药物最为敏感。美罗培南对巴西诺卡菌和豚鼠耳炎诺卡菌的活性均高于亚胺培南，其MIC50值为28.3 - 53.3mg/L。L-627的活性低于美罗培南。
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