Hendrie Hugh C, Hall Kathleen S, Ogunniyi Adesola, Gao Sujuan
Department of Psychiatry, Indiana University School of Medicine, Indiana University Center for Aging Research, Indianapolis 46202-2872, USA.
Can J Psychiatry. 2004 Feb;49(2):92-9. doi: 10.1177/070674370404900203.
To describe the construction of a disease model incorporating both genetic an environmental factors in the etiology of Alzheimer's disease (AD), using data generated from the Indianapolis-Ibadan dementia project (I-IDP).
The I-IDP is a longitudinal comparative study of the prevalence and incidence o dementia in 2 communities: elderly African Americans living in Indianapolis, Indiana, an Yoruba living in Ibadan, Nigeria.
African Americans are more than twice as likely as Yoruba to develop AD. Possible explanations for this finding include genetic factors: the possession of the apolipoprotein E epsilon4 allele does not increase risk for AD among Yoruba but confers a sligh increase in AD risk for African Americans. As well, environmental factors may play a role: African Americans have a higher risk of vascular risk factors than do Yoruba.
International comparative studies, particularly those involving population from developing and developed countries, offer a unique opportunity for applying new in formation regarding population genetics to traditional AD risk factor research.
利用印第安纳波利斯-伊巴丹痴呆项目（I-IDP）生成的数据，描述一种将遗传和环境因素纳入阿尔茨海默病（AD）病因的疾病模型构建。
I-IDP是对两个社区痴呆症患病率和发病率的纵向比较研究：居住在印第安纳州印第安纳波利斯的老年非裔美国人以及居住在尼日利亚伊巴丹的约鲁巴人。
非裔美国人患AD的可能性是约鲁巴人的两倍多。这一发现的可能解释包括遗传因素：载脂蛋白E ε4等位基因的存在不会增加约鲁巴人患AD的风险，但会使非裔美国人患AD的风险略有增加。此外，环境因素可能也起作用：非裔美国人患血管危险因素的风险高于约鲁巴人。
国际比较研究，特别是那些涉及发展中国家和发达国家人群的研究，为将有关群体遗传学的新信息应用于传统AD危险因素研究提供了独特机会。
