不对称自催化及其对同手性起源的影响。
Asymmetric autocatalysis and its implications for the origin of homochirality.
作者信息
Blackmond Donna G
机构信息
Department of Chemistry, Imperial College, London SW7 2AZ, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5732-6. doi: 10.1073/pnas.0308363101. Epub 2004 Apr 5.
Abstract
An autocatalytic reaction in which the reaction product serves as a catalyst to produce more of itself and to suppress production of its enantiomer serves as a mechanistic model for the evolution of homochirality. The Soai reaction provided experimental confirmation of this concept, nearly 50 years after it was first proposed. This Perspective offers a rationalization of the Soai autocatalytic reaction; accounting for enantiomeric excess and rate observations, that is both simple as well as gratifying in its implications for the chemical origin of life.
摘要
一种自催化反应，其中反应产物作为催化剂来产生更多自身，并抑制其对映体的产生，可作为同手性进化的一种机制模型。在首次提出近50年后，索艾反应为这一概念提供了实验证实。本视角文章对索艾自催化反应进行了合理化解释；解释了对映体过量和速率观察结果，既简单又令人满意，因为其对生命的化学起源具有重要意义。
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