Loukili N Henoun, Andrès E
Service de Médecine Interne, Diabète et Maladies Métaboliques de la Clinique Médicale B des Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.
Ann Endocrinol (Paris). 2003 Nov;64(5 Pt 1):376-82.
Update on cobalamin deficiencies in adults.
More precise definitions establish real cobalamin deficiency and determine epidemiological features. Current data on cobalamin metabolism suggest the concept of non-dissociation of vitamin B12 from its carrier proteins (NDB12), a generalization of the food-cobalamin malabsorption concept. The new features of cobalamin deficiency include neurological, gynecological and vascular manifestations. Current treatment modalities include nasal and oral administration of cobalamin.
Validate the concept of NDB12 and the usefulness of oral cobalamin therapy, establish the relevance of the new clinical manifestations.
更新成人钴胺素缺乏症相关内容。
更精确的定义确立了真正的钴胺素缺乏症并确定了流行病学特征。目前关于钴胺素代谢的数据提出了维生素B12与其载体蛋白不分离（NDB12）的概念，这是食物钴胺素吸收不良概念的推广。钴胺素缺乏症的新特征包括神经、妇科和血管方面的表现。当前的治疗方式包括鼻腔和口服钴胺素。
验证NDB12概念以及口服钴胺素疗法的有效性，确定新临床表现的相关性。
