[Vitamin B12 in the adult: of metabolism and deficiencies].

PURPOSE

Update on cobalamin deficiencies in adults.

CURRENT KNOWLEDGE AND KEY POINTS

More precise definitions establish real cobalamin deficiency and determine epidemiological features. Current data on cobalamin metabolism suggest the concept of non-dissociation of vitamin B12 from its carrier proteins (NDB12), a generalization of the food-cobalamin malabsorption concept. The new features of cobalamin deficiency include neurological, gynecological and vascular manifestations. Current treatment modalities include nasal and oral administration of cobalamin.

PROSPECTS AND PROJECTS

Validate the concept of NDB12 and the usefulness of oral cobalamin therapy, establish the relevance of the new clinical manifestations.