Nordström M, Lindblad B, Bergqvist D, Kjellström T
Department of Medicine, Malmö General Hospital, University of Lund, Sweden.
J Intern Med. 1992 Aug;232(2):155-60. doi: 10.1111/j.1365-2796.1992.tb00565.x.
In a prospective study all positive phlebographies within the well-defined population of the city of Malmö, Sweden, during 1987 were studied in order to determine the incidence of deep venous thrombosis (DVT). Epidemiological data were analysed for the detection of patient groups at increased risk of DVT. The incidence was found to be equal for both sexes, i.e. 1.6 per 1000 inhabitants a year. Risk factors were found to be in accordance with earlier studies. The median age for men was 66 years, compared to 72 years for women. At diagnosis of DVT, 19% of subjects had a known malignancy and within 1 year 5% (19 cases) developed a new malignancy. Of the men, 29% had postoperative or post-traumatic (fracture) DVT, compared to 46% of the women. Fewer patients with DVT than expected (39%) belonged to blood group 0 (31%) (P less than 0.005). Pulmonary embolism (PE) was clinically suspected in only 5% of cases, and diagnosis was verified scintigraphically in 2% of cases. None of these died of PE, but of 6 patients who were found to have PE at autopsy, four died about 4 weeks after the DVT was diagnosed.
在一项前瞻性研究中，对瑞典马尔默市明确界定人群中1987年所有阳性静脉造影进行了研究，以确定深静脉血栓形成（DVT）的发病率。分析了流行病学数据，以检测DVT风险增加的患者群体。发现两性发病率相等，即每年每1000名居民中有1.6例。发现危险因素与早期研究一致。男性的中位年龄为66岁，女性为72岁。在诊断为DVT时，19%的受试者患有已知恶性肿瘤，在1年内5%（19例）发生了新的恶性肿瘤。男性中，29%患有术后或创伤后（骨折）DVT，女性为46%。患有DVT的患者中，属于0血型（31%）的人数低于预期（39%）（P<0.005）。仅5%的病例临床怀疑有肺栓塞（PE），2%的病例经闪烁扫描证实诊断。这些患者均未死于PE，但在尸检中发现有PE的6例患者中，有4例在DVT诊断后约4周死亡。
