Krajcovicová-Kudlácková M, Pauková V, Baceková M, Dusinská M
Slovak Health University, Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Cent Eur J Public Health. 2004 Mar;12(1):46-8.
Oxidative stress plays an important contributory role in the pathogenesis of age-related chronic diseases. Increased lipid peroxidation process is caused by an enhanced free radical formation together with a higher supply of substrates and by an insufficient defense by antioxidants as well. Levels of malondialdehyde to content of lipid peroxidation substrates (polyunsaturated fatty acids), promoters (homocysteine--hydroxyl radical producer) and inhibitors (essential vitamins C and E) were estimated in a group (n=92) of subjective healthy adults randomly selected from general population. The relationship of malondialdehyde levels to values of peroxidisability index of fatty acids as well as to levels of homocysteine is significantly positive linear A significant inverse linear correlation between malondialdehyde levels and natural antioxidant levels (vitamin C, vitamin E) was recorded. Lipid peroxidation products (conjugated dienes of fatty acids--initial, malondialdehyde--secondary) are significantly increased in groups of subjects with deficient levels of vitamin C (below the limit from antioxidative point of view), vitamin E and both vitamins, if compared to group with normal vitamin levels (over limit in accordance with antioxidative criterion). The results document that the deficiency in two key antioxidants for lipid peroxidation inhibition means the insufficient defense against free radicals and the increased lipid peroxidation.
氧化应激在与年龄相关的慢性疾病发病机制中起着重要的促成作用。自由基生成增加、底物供应增多以及抗氧化剂防御不足共同导致脂质过氧化过程加剧。在一组从普通人群中随机选取的主观健康成年人（n = 92）中，评估了丙二醛水平与脂质过氧化底物（多不饱和脂肪酸）、促进剂（同型半胱氨酸——羟基自由基产生剂）和抑制剂（必需维生素C和E）含量的关系。丙二醛水平与脂肪酸过氧化能力指数值以及同型半胱氨酸水平呈显著正线性关系。丙二醛水平与天然抗氧化剂水平（维生素C、维生素E）之间存在显著负线性相关。与维生素水平正常的组（根据抗氧化标准超过限值）相比，维生素C水平不足（从抗氧化角度低于限值）、维生素E水平不足以及两种维生素均不足的受试者组中，脂质过氧化产物（脂肪酸共轭二烯——初级产物，丙二醛——次级产物）显著增加。结果表明，抑制脂质过氧化的两种关键抗氧化剂缺乏意味着对自由基的防御不足以及脂质过氧化增加。
