Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Arch Dermatol Res. 2009 Oct;301(10):731-7. doi: 10.1007/s00403-009-0964-4. Epub 2009 Jun 2.
Vitiligo is an acquired skin disease, characterized by white areas on the skin due to loss of functional melanocytes. The pathogenesis of the disease is still unclear. Published data show the involvement of oxidative stress in the pathophysiology of vitiligo. A total of 30 vitiligo patients and 30 healthy controls were included in this study. We estimated serum levels of malondialdehyde (MDA), vitamins E and C, total antioxidant activity and whole blood levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in vitiligo patients and controls. We found significantly higher levels of MDA and significantly lower levels of SOD, GPx, vitamins C and E and total antioxidant activity in vitiligo patients compared with controls. This study is a maiden attempt to report on antioxidant parameters of both generalized/localized-type Indian vitiligo patients. Our results confirmed that oxidative stress may play an important role in the pathogenesis of vitiligo and cause melanocyte damage in vitiligo.
白癜风是一种获得性皮肤疾病，其特征是由于功能性黑素细胞丧失而导致皮肤出现白色区域。该疾病的发病机制尚不清楚。已发表的数据表明，氧化应激参与了白癜风的病理生理学过程。本研究纳入了 30 名白癜风患者和 30 名健康对照者。我们评估了白癜风患者和对照组的血清丙二醛（MDA）、维生素 E 和 C、总抗氧化活性以及全血超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）水平。与对照组相比，白癜风患者的 MDA 水平显著升高，SOD、GPx、维生素 C 和 E 以及总抗氧化活性水平显著降低。这是首次报告印度泛发性/局限性白癜风患者的抗氧化参数。我们的结果证实，氧化应激可能在白癜风的发病机制中起重要作用，并导致白癜风患者的黑素细胞损伤。
