Kim Y, DiSilvestro R, Clinton S
Human Nutrition, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210-1295, USA.
Phytomedicine. 2004 Feb;11(2-3):152-6. doi: 10.1078/0944-7113-00282.
The carotenoid lycopene has been touted as possessing various antioxidant properties, but there are no demonstrations that lycopene inhibits tissue injury due to acute oxidant stress. Thus, the present study examined the effects of intake of lycopene or tomato extract, a rich source of lycopene, on acute liver injury caused by the oxidant carbon tetrachloride (CCl4). Feeding with tomato extract (10% tomato powder), but not with lycopene (0.25% lycopene beadlets), partially inhibited CCl4-induced hepatic injury based on the serum activities of sorbitol dehydrogenase and aspartate aminotransferase. No effect was seen for either lycopene or tomato extract on serum beta-glucuronidase activity, a marker of lysosomal injury. We concluded that tomato extract, but not lycopene, partially protected against acute liver injury due to chemically-induced oxidant stress.
类胡萝卜素番茄红素一直被吹捧具有多种抗氧化特性，但尚无证据表明番茄红素能抑制急性氧化应激导致的组织损伤。因此，本研究检测了摄入番茄红素或番茄提取物（富含番茄红素）对由氧化剂四氯化碳（CCl4）引起的急性肝损伤的影响。基于山梨醇脱氢酶和天冬氨酸氨基转移酶的血清活性，喂食番茄提取物（10%番茄粉）而非番茄红素（0.25%番茄红素微粒）可部分抑制CCl4诱导的肝损伤。番茄红素或番茄提取物对作为溶酶体损伤标志物的血清β-葡萄糖醛酸酶活性均无影响。我们得出结论，番茄提取物而非番茄红素可部分预防化学诱导的氧化应激所致的急性肝损伤。
