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十种草药提取物对四氯化碳致肝损伤的保肝作用

The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver.

作者信息

Rusu M A, Tamas M, Puica C, Roman Ioana, Sabadas Mihaela

机构信息

Institute of Biological Research, Cluj-Napoca, Romania.

出版信息

Phytother Res. 2005 Sep;19(9):744-9. doi: 10.1002/ptr.1625.

Abstract

The effect of ten phytotherapeutic products on CCl(4) intoxicated liver in albino male Wistar rats was investigated. Biochemical parameters, including serum transaminase activity (GPT and GOT), histoenzymological measurements (lactate dehydrogenase, LDH; succinate dehydrogenase, SDH, cytochromoxidase, CyOx; Mg(2+)-dependent adenosine triphosphatase, ATP-ase) and histochemical (Sudan black) and histological examinations (haematoxylin-eosin staining) of the liver were investigated. Some positive effects such as the reduction of hepatocytolysis and steatosis, and a return to normal values of the activity of some enzymes in the following plants: Chrysanthemum balsamita, Echinacea pallida, Calendula officinalis and Corylus avelana were obtained.

摘要

研究了十种植物治疗产品对白化雄性Wistar大鼠四氯化碳中毒肝脏的影响。对包括血清转氨酶活性(谷丙转氨酶和谷草转氨酶)、组织酶学测量(乳酸脱氢酶、琥珀酸脱氢酶、细胞色素氧化酶、镁离子依赖性三磷酸腺苷酶)以及肝脏的组织化学(苏丹黑)和组织学检查(苏木精-伊红染色)在内的生化参数进行了研究。在以下植物中获得了一些积极效果,如肝细胞溶解和脂肪变性的减轻以及某些酶活性恢复到正常水平:香脂菊、淡紫松果菊、金盏花和榛树。

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