Tabayashi K, Takahashi G, Motoyoshi N, Kokubo H, Sakurai M, Oda K, Saiki Y, Iguchi A
Department of Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan.
Kyobu Geka. 2004 Apr;57(4):301-6.
The purpose of this study is to evaluate usefulness of perfusion cooling for regional spinal cord hypothermia during most or all of thoracic or thoracoabdominal aneurysm repair.
From 1987 to 2003, 103 patients underwent most or all of thoracic or thoracoabdominal aneurysm repair. Forty-eight patients underwent operation using distal aortic perfusion, mild hypothermia and segment sequential repair (group MH). Fifty-five patients underwent the same operation as group MH except epidural perfusion cooling and drainage of cerebrospinal fluid (CSF) [group EC & CSFD]. The aorta was replaced sequentially in segment and several paris of intercostal and lumbar arteries were reconstructed in 2 groups.
Cardiopulmonary bypass time of group MH and group EC & CSFD was averaged 235 and 241 minutes, respectively. The lowest CSF temperature in group EC & CSFD was averaged 24.7 degrees C, and the difference between nasopharyngeal and CSF temperature was averaged 6.4 degrees C. The rate of spinal cord injury of group MH and EC & CSFD was 10.4% and 3.6%, respectively. Hospital mortality of group MH and EC & CSFD was 8.3% and 5.5%, respectively. The incidence of spinal cord injury and hospital mortality of group EC & CSFD were decreased compared to them of group MH.
We conclude that the perfusion cooling of epidural space and CSF drainage are effective method in reducing postoperative spinal cord injury.
本研究旨在评估在大多数或全部胸段或胸腹段动脉瘤修复术中,灌注冷却用于区域脊髓低温的有效性。
1987年至2003年,103例患者接受了大多数或全部胸段或胸腹段动脉瘤修复术。48例患者采用远端主动脉灌注、轻度低温和节段顺序修复进行手术(MH组)。55例患者接受了与MH组相同的手术,但增加了硬膜外灌注冷却和脑脊液引流(EC & CSFD组)。两组均依次进行节段性主动脉置换,并重建多对肋间动脉和腰动脉。
MH组和EC & CSFD组的体外循环时间平均分别为235分钟和241分钟。EC & CSFD组脑脊液最低温度平均为24.7℃,鼻咽温度与脑脊液温度的差值平均为6.4℃。MH组和EC & CSFD组的脊髓损伤发生率分别为10.4%和3.6%。MH组和EC & CSFD组的医院死亡率分别为8.3%和5.5%。与MH组相比,EC & CSFD组的脊髓损伤发生率和医院死亡率均有所降低。
我们得出结论,硬膜外间隙灌注冷却和脑脊液引流是减少术后脊髓损伤的有效方法。