Geuna Stefano, Tos Pierluigi, Battiston Bruno, Giacobini-Robecchi Maria G
Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Ospedale San Luigi, Regione Gonzole 10, 10043-Orbassano, TO, Italy.
Neurol Res. 2004 Mar;26(2):139-44. doi: 10.1179/016164104225013752.
Various tubulization techniques can be used to bridge peripheral nerve lesions with substance loss. Among the different materials that have been used so far in alternative to traditional fresh nerve autografts, fresh muscle-vein combined conduits (made by a vein segment filled with fresh skeletal muscle) proved to be particularly effective. In this study, nerve repair of 10-mm long nerve defects by means of muscle-vein combined tubes was compared with repair by means of traditional nerve autografts in the rat sciatic nerve experimental model. Results did not reveal any significant difference between the two groups of regenerated nerves with respect to the total number, mean density and mean size of myelinated nerve fibers. In addition, we also report the results of an experimental study in the rabbit sciatic nerve model, which showed that fresh skeletal muscle enrichment of the vein segment made it possible to bridge 55-mm long nerve gaps. These results provide further evidence of the effectiveness of fresh muscle-vein combined grafts and support the view that this type of conduit can be used also for repairing long nerve gaps.
可以采用多种管道化技术来桥接存在实质缺损的周围神经损伤。在迄今为止用于替代传统新鲜神经自体移植的不同材料中，新鲜肌肉 - 静脉联合导管（由一段填充有新鲜骨骼肌的静脉制成）已被证明特别有效。在本研究中，在大鼠坐骨神经实验模型中，将通过肌肉 - 静脉联合导管修复10毫米长神经缺损的效果与通过传统神经自体移植进行修复的效果进行了比较。结果显示，两组再生神经在有髓神经纤维的总数、平均密度和平均大小方面均未发现任何显著差异。此外，我们还报告了在兔坐骨神经模型中的一项实验研究结果，该结果表明，静脉段富含新鲜骨骼肌能够桥接55毫米长的神经间隙。这些结果进一步证明了新鲜肌肉 - 静脉联合移植物的有效性，并支持了这种类型的导管也可用于修复长神经间隙的观点。
