Brunelli G A, Battiston B, Vigasio A, Brunelli G, Marocolo D
Clinica Ortopedica, Universita di Brescia, Italy.
Microsurgery. 1993;14(4):247-51. doi: 10.1002/micr.1920140407.
The use of vein or muscle grafts to bridge nerve defects longer than 1-1.5 cm gives poor results. Veins collapse and in muscle grafts axons may regrow outside the graft. We used veins (to guide regeneration) filled with muscle (to avoid vein collapse). Nerve regeneration through 1 and 2 cm grafts made of vein plus muscle was compared with similarly long traditional nerve grafts, free fresh muscle grafts, and empty vein grafts. Regeneration was assessed clinically and histologically (qualitative and quantitative evaluation) in the graft and distal nerve stumps. Vein plus muscle grafts were superior to vein and fresh muscle grafts both functionally and histologically. Functional results were similar to those found in traditional nerve grafts, but axon number was superior in the veins filled with muscle. This suggests that vein filled with muscle might serve as a grafting conduit for the repair of peripheral nerve injuries and could give better results than traditional nerve grafting.
使用静脉或肌肉移植物来桥接超过1 - 1.5厘米的神经缺损，效果不佳。静脉会塌陷，而在肌肉移植物中，轴突可能会在移植物外再生。我们使用填充有肌肉的静脉（以引导再生）来避免静脉塌陷。将由静脉加肌肉制成的1厘米和2厘米移植物的神经再生情况与同样长度的传统神经移植物、游离新鲜肌肉移植物和空静脉移植物进行比较。在移植物和远端神经残端进行了临床和组织学评估（定性和定量评价）。静脉加肌肉移植物在功能和组织学方面均优于静脉和新鲜肌肉移植物。功能结果与传统神经移植物相似，但填充有肌肉的静脉中的轴突数量更多。这表明填充有肌肉的静脉可能作为修复周围神经损伤的移植管道，并且可能比传统神经移植产生更好的效果。
