Wu Ruijin, Van der Hoek Kylie H, Ryan Natalie K, Norman Robert J, Robker Rebecca L
Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville Road, Woodville, South Australia 5011.
Hum Reprod Update. 2004 Mar-Apr;10(2):119-33. doi: 10.1093/humupd/dmh011.
Macrophages are multifunctional cells that play key roles in the immune response and are abundant throughout female reproductive tissues. Macrophages are identified in tissues by their expression of cell surface receptors and can execute diverse functional activities, including phagocytosis and degradation of foreign antigens, matrix dissolution and tissue remodelling, and production and secretion of cytokines, chemokines and growth factors. Their specific localization and variations in distribution in the ovary during different stages of the cycle, as well as their presence in peri-ovulatory human follicular fluid, suggest that macrophages play diverse roles in intra-ovarian events including folliculogenesis, tissue restructuring at ovulation and corpus luteum formation and regression. This review presents the existing evidence for the regulation of ovarian function by macrophages and macrophage-derived products, highlighting the implications of these cells in ovarian diseases, particularly polycystic ovary syndrome, endometriosis and premature ovarian failure.
巨噬细胞是多功能细胞，在免疫反应中起关键作用，且在整个女性生殖组织中大量存在。巨噬细胞通过其细胞表面受体的表达在组织中得以识别，并可执行多种功能活动，包括吞噬和降解外来抗原、基质溶解和组织重塑，以及细胞因子、趋化因子和生长因子的产生与分泌。它们在卵巢周期不同阶段的特定定位和分布变化，以及在人排卵周围卵泡液中的存在，表明巨噬细胞在卵巢内事件中发挥多种作用，包括卵泡发生、排卵时的组织重构以及黄体形成和退化。本综述展示了巨噬细胞及巨噬细胞衍生产物对卵巢功能调节的现有证据，强调了这些细胞在卵巢疾病，特别是多囊卵巢综合征、子宫内膜异位症和卵巢早衰中的意义。
