von Schacky Clemens
Medical Clinic and Policlinic Innenstadt, University of Munich, Ziemssenstrasse 1, D-80336 Munich, Germany.
Curr Opin Clin Nutr Metab Care. 2004 Mar;7(2):131-6. doi: 10.1097/00075197-200403000-00005.
Omega-3 fatty acids are gaining acceptance in the cardiovascular field. The present review describes the most recent studies and developments in the field.
Marine omega-3 fatty acids, that is eicosapentaenoic and docosahexaenoic acids, prevent fatal myocardial infarction and sudden cardiac death by their antiarrhythmic effects and presumably also by their effect on infarct size, the latter mediated by plaque stabilization, improvements in endothelial function and other mechanisms. In contrast, a cardioprotective effect of alpha-linolenic acid, a plant-derived omega-3 fatty acid, remains to be clearly demonstrated in adequate intervention trials. Other forms of applications, like parenteral use or other indications, like in the psychiatric field, are currently being actively investigated.
Eicosapentaenoic and docosahexaenoic acids, but not alpha-linolenic acid, prevent sudden death and other cardiovascular catastrophies, and have therefore been recently incorporated into the pertinent guidelines of European and American cardiologic societies.
ω-3脂肪酸在心血管领域正逐渐得到认可。本综述描述了该领域的最新研究和进展。
海洋来源的ω-3脂肪酸，即二十碳五烯酸和二十二碳六烯酸，通过其抗心律失常作用以及可能通过对梗死面积的影响（后者由斑块稳定、内皮功能改善及其他机制介导）预防致命性心肌梗死和心源性猝死。相比之下，植物来源的ω-3脂肪酸α-亚麻酸的心脏保护作用在充分的干预试验中仍有待明确证实。其他应用形式，如肠外使用或其他适应证，如在精神科领域，目前正在积极研究中。
二十碳五烯酸和二十二碳六烯酸可预防猝死和其他心血管灾难性事件，而α-亚麻酸则不能，因此最近已被纳入欧美心脏病学会的相关指南。
