Kurlan Roger
Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642-8673, USA.
Mov Disord. 2004 Apr;19(4):433-7. doi: 10.1002/mds.10625.
We report on 6 patients with Parkinson's disease who developed severe repetitive behavior, 2 with pathological gambling and 4 with cleaning, rearranging, and ordering rituals. The onset of repetitive behaviors was not associated with changes in antiparkinsonian medications, the behavior did not improve after reductions in dopaminergic therapy, and thus they seem to be part of the underlying illness. The disabling cleaning/rearranging/ordering behaviors had associated features of hypomania, occurred exclusively during motor on periods, and often occurred nocturnally. The repetitive behavior responded poorly to serotonin reuptake inhibitors. Certain atypical antipsychotics may be of benefit.
我们报告了6例帕金森病患者出现严重的重复行为，其中2例患有病理性赌博，4例有清洁、重新整理和排序仪式行为。重复行为的发作与抗帕金森病药物的变化无关，减少多巴胺能治疗后行为并未改善，因此它们似乎是潜在疾病的一部分。致残性的清洁/重新整理/排序行为具有轻躁狂的相关特征，仅在运动开启期出现，且常发生在夜间。重复行为对5-羟色胺再摄取抑制剂反应不佳。某些非典型抗精神病药物可能有益。
