Bousquet C, Guillermet J, Vernejoul F, Lahlou H, Buscail L, Susini C
INSERM U531, IFR 31, CHU Rangueil, 31403 Toulouse Cedex 4, France.
Dig Liver Dis. 2004 Feb;36 Suppl 1:S2-7. doi: 10.1016/j.dld.2003.11.007.
Somatostatin is an inhibitory neuropeptide, which acts on various targets throughout the body to regulate a variety of physiological functions including inhibition of endocrine and exocrine secretions, modulation of neurotransmission, motor and cognitive functions, inhibition of intestinal motility, absorption of nutrients and ions, vascular contractility and inhibition of normal and tumour cell proliferation. It exerts its effects through interaction with five somatostatin receptors (sst1-sst5), which belong to the family of G-protein-coupled receptors with seven transmembrane spanning domains and are variably expressed in a variety of tumours such as gastroenteropancreatic tumours, pituitary tumours, and carcinoid tumours. This review covers the present knowledge regarding the molecular mechanisms involved in somatostatin antineoplastic activity. Evidence that sst2 receptor acts as a tumour suppressor is also discussed.
生长抑素是一种抑制性神经肽，它作用于全身的各种靶点，以调节多种生理功能，包括抑制内分泌和外分泌、调节神经传递、运动和认知功能、抑制肠道蠕动、营养物质和离子的吸收、血管收缩以及抑制正常细胞和肿瘤细胞的增殖。它通过与五种生长抑素受体（sst1 - sst5）相互作用发挥作用，这些受体属于具有七个跨膜结构域的G蛋白偶联受体家族，并在多种肿瘤中差异表达，如胃肠胰腺肿瘤、垂体肿瘤和类癌肿瘤。本综述涵盖了目前关于生长抑素抗肿瘤活性所涉及分子机制的知识。还讨论了sst2受体作为肿瘤抑制因子的证据。
