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[呼出气冷凝物在支气管哮喘患者支气管内容物生物化学研究中的应用]

[Use of the expired air condensate in the study of biochemistry of bronchial contents in patients with bronchial asthma].

作者信息

Fedoseev G B, Emel'ianov A V, Malakauskas K K, Goncharov V A, Emanuèl' V L, Kakliugin A P

出版信息

Klin Med (Mosk). 1992 Mar-Apr;70(3-4):27-8.

PMID:1507840
Abstract

A total of 7 patients with premorbid adjustment (PA) and 13 patients with bronchial asthma (BA) were comparatively studied for the content of calcium, magnesium and biogenic amines (histamine, serotonin) which were assessed with atom absorption spectrophotometry and fluorimetry in the condensate of expired air (CEA), fluid of the bronchial wash-off (FBW) and bronchoalveolar lavage (BAL). It was revealed that the studied values in CEA were similar to those in FBW and BAL. The results obtained indicated that CEA adequately demonstrated the biochemical composition of bronchial contents in various generations and alveoli. CEA availability and high informative value permitted it to be employed in the research into the mechanisms of bronchial obstruction as well as in the control for the efficacy of BA and PA treatment.

摘要

对7例病前适应(PA)患者和13例支气管哮喘(BA)患者进行了比较研究,通过原子吸收分光光度法和荧光法测定呼出气冷凝物(CEA)、支气管冲洗液(FBW)和支气管肺泡灌洗(BAL)中钙、镁和生物胺(组胺、5-羟色胺)的含量。结果发现,CEA中的研究值与FBW和BAL中的相似。所得结果表明,CEA能充分显示各级支气管内容物和肺泡的生化组成。CEA的可得性和高信息价值使其可用于研究支气管阻塞机制以及控制BA和PA的治疗效果。

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