Ranganathan K, Devi M Uma, Joshua Elizabeth, Kirankumar K, Saraswathi T R
Department of Oral Pathology, Ragas Dental College and Hospital, Chennai, India.
J Oral Pathol Med. 2004 May;33(5):274-7. doi: 10.1111/j.0904-2512.2004.00116.x.
Oral submucous fibrosis (OSF) is a pre-cancerous condition caused by the use of areca nut in various forms. There are very few published reports on areca nut use and OSF from Chennai, South India.
A hospital-based case-control study on habits and OSF was performed in Chennai over a 3-year period. A total of 185 consecutive patients with OSF were matched with age- and sex-matched controls. History was recorded in a pre-determined format by qualified dental surgeons.
The male to female ratio of OSF cases was 9.9 : 1. All areca nut products were associated with OSF, with the risk being greatest for pan masala. The duration of the habit was more significant than the frequency of the chewing habit.
The present study confirms the strong association between areca nut use and OSF and the increasing use of pan masala.
口腔黏膜下纤维化（OSF）是一种由食用各种形式槟榔引起的癌前病变。来自印度南部钦奈的关于槟榔使用与口腔黏膜下纤维化的已发表报告非常少。
在钦奈进行了一项为期3年的基于医院的关于习惯与口腔黏膜下纤维化的病例对照研究。总共185例口腔黏膜下纤维化连续患者与年龄和性别匹配的对照组进行了匹配。由合格的牙科医生以预先确定的格式记录病史。
口腔黏膜下纤维化病例的男女比例为9.9:1。所有槟榔制品都与口腔黏膜下纤维化有关，其中嚼烟的风险最大。习惯持续时间比咀嚼频率更显著。
本研究证实了槟榔使用与口腔黏膜下纤维化之间的密切关联以及嚼烟使用的增加。
