Shah N, Sharma P P
Department of Dental Surgery, All India Institute of Medical Sciences, New Delhi.
J Oral Pathol Med. 1998 Nov;27(10):475-9. doi: 10.1111/j.1600-0714.1998.tb01915.x.
Oral submucous fibrosis (OSF), a premalignant and crippling condition of the oral mucous membrane, was studied to identify its relationship to various chewing and smoking habits. Two hundred and thirty-six consecutive cases of OSF were compared with 221 control subjects matched for age, sex and socio-economic conditions. It was found that chewing of areca nut/quid or pan masala (a commercial preparation of areca nuts, lime, catechu and undisclosed colouring, flavouring and sweetening agents) was directly related to OSF. Also, pan masala was chewed by a comparatively younger age group and was associated with OSF changes earlier than areca nut/quid chewing. However, chewing or smoking tobacco with various other chewing habits did not increase the risk of developing OSF. It was also found that frequency of chewing rather than the total duration of the habit was directly correlated to OSF.
口腔黏膜下纤维化（OSF）是一种口腔黏膜的癌前致残性疾病，本研究旨在确定其与各种咀嚼和吸烟习惯的关系。将236例连续的口腔黏膜下纤维化病例与221名年龄、性别和社会经济状况相匹配的对照受试者进行比较。研究发现，咀嚼槟榔/槟榔块或潘趣酒（一种由槟榔、石灰、儿茶以及未公开的着色、调味和甜味剂制成的商业制剂）与口腔黏膜下纤维化直接相关。此外，相对年轻的年龄组会咀嚼潘趣酒，并且与口腔黏膜下纤维化变化的关联早于咀嚼槟榔/槟榔块。然而，将咀嚼烟草或吸烟与各种其他咀嚼习惯相结合并不会增加患口腔黏膜下纤维化的风险。研究还发现，咀嚼频率而非习惯的总时长与口腔黏膜下纤维化直接相关。
