Solovieva S, Leino-Arjas P, Saarela J, Luoma K, Raininko R, Riihimäki H
Department of Epidemiology and Biostatistics, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, Helsinki 00250, Finland.
Pain. 2004 May;109(1-2):8-19. doi: 10.1016/j.pain.2003.10.020.
Based on a hypothesis that interleukin 1 (IL-1) activity is associated with low back pain (LBP), we investigated relationships between previously described functional IL-1 gene polymorphisms and LBP. The subjects were a subgroup of a Finnish study cohort. The IL-1alpha(C(889)-T), IL-1beta(C(3954)-T) and IL-1 receptor antagonist (IL-1RN)(G(1812)-A, G(1887)-C and T(11100)-C) polymorphisms were genotyped in 131 middle-aged men from three occupational groups (machine drivers, carpenters and office workers). A questionnaire inquired about individual and lifestyle characteristics and the occurrence of LBP, the number of days with pain and days with limitation of daily activities because of pain, and pain intensity, during the past 12 months. Lumbar disc degeneration was determined with magnetic resonance imaging. Carriers of the IL-1RNA(1812) allele had an increased risk of LBP (OR 2.5, 95% CI 1.0-6.0) and carriers of this allele in combination with the IL-1alphaT(889) or IL-1betaT(3954) allele had a higher risk of and more days with LBP than non-carriers. Pain intensity was associated with the simultaneous carriage of the IL-1alphaT(889) and IL-1RNA(1812) alleles (OR 3.7, 95% CI 1.2-11.9). Multiple regression analyses allowing for occupation and disc degeneration showed that carriage of the IL-1RNA(1812) allele was associated with the occurrence of pain, the number of days with pain and days with limitations of daily activities. Carriage of the IL-1betaT(3954) allele was associated with the number of days with pain. The results suggest a possible contribution of the IL-1 gene locus polymorphisms to the pathogenesis of LBP. The possibility of chance findings cannot be excluded due to the small sample size.
基于白细胞介素1（IL-1）活性与腰痛（LBP）相关的假设，我们研究了先前描述的功能性IL-1基因多态性与LBP之间的关系。研究对象是芬兰一项研究队列中的一个亚组。对来自三个职业组（机器驾驶员、木匠和办公室职员）的131名中年男性进行了IL-1α（C(889)-T）、IL-1β（C(3954)-T）和白细胞介素1受体拮抗剂（IL-1RN）（G(1812)-A、G(1887)-C和T(11100)-C）多态性的基因分型。一份问卷询问了个人和生活方式特征以及LBP的发生情况、疼痛天数、因疼痛导致日常活动受限的天数以及过去12个月内的疼痛强度。通过磁共振成像确定腰椎间盘退变情况。IL-1RNA(1812)等位基因携带者患LBP的风险增加（比值比2.5，95%置信区间1.0 - 6.0），该等位基因与IL-1αT(889)或IL-1βT(3954)等位基因同时存在的携带者比非携带者患LBP的风险更高且疼痛天数更多。疼痛强度与IL-1αT(889)和IL-1RNA(1812)等位基因同时携带有关（比值比3.7，95%置信区间1.2 - 11.9）。考虑职业和椎间盘退变的多元回归分析表明，IL-1RNA(1812)等位基因的携带与疼痛的发生、疼痛天数以及日常活动受限天数有关。IL-1βT(3954)等位基因的携带与疼痛天数有关。结果提示IL-1基因位点多态性可能在LBP发病机制中起作用。由于样本量小，不能排除偶然发现的可能性。
