关节疾病中的趋化因子：炎症的关键所在？
Chemokines in joint disease: the key to inflammation?
作者信息
Haringman J J, Ludikhuize J, Tak P P
机构信息
Division of Clinical Immunology and Rheumatology, F4-218, Department of Internal Medicine, Academic Medical Centre/University of Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands.
出版信息
Ann Rheum Dis. 2004 Oct;63(10):1186-94. doi: 10.1136/ard.2004.020529. Epub 2004 Apr 13.
Abstract
Targeting chemokines and/or chemokine receptors appears to be an intriguing new approach to treating chronic inflammatory disorders like rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and transplant rejections. The involvement of chemokines and chemokine receptors in inflammatory joint diseases, the in vitro and in vivo characteristics of the chemokine family in inflammatory joint disease, and initial clinical data on chemokine blockade in patients with rheumatoid arthritis suggest that targeting the chemokine and chemokine receptor family might provide a new, promising antirheumatic strategy.
摘要
靶向趋化因子和/或趋化因子受体似乎是一种治疗类风湿性关节炎、炎症性肠病、多发性硬化症和移植排斥等慢性炎症性疾病的新方法。趋化因子和趋化因子受体在炎症性关节疾病中的作用、炎症性关节疾病中趋化因子家族的体外和体内特征，以及类风湿性关节炎患者趋化因子阻断的初步临床数据表明，靶向趋化因子和趋化因子受体家族可能提供一种新的、有前景的抗风湿策略。
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