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本文引用的文献

1
Indifference of subjects: an alternative to equipoise in randomized clinical trials.受试者的无差别状态:随机临床试验中均衡性的一种替代方案
Soc Philos Policy. 2002 Summer;19(2):295-323. doi: 10.1017/s0265052502192120.
2
The Declaration of Helsinki and clinical trials: a focus on placebo-controlled trials in schizophrenia.《赫尔辛基宣言》与临床试验:聚焦精神分裂症的安慰剂对照试验
Am J Psychiatry. 2003 Feb;160(2):356-62. doi: 10.1176/appi.ajp.160.2.356.
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The virtues of evidence.证据的优点。
Theor Med Bioeth. 2002;23(4-5):403-12. doi: 10.1023/a:1021217908383.
4
Equipoise, knowledge and ethics in clinical research and practice.临床研究与实践中的 equipoise(平衡)、知识与伦理。 (注:equipoise 这个词在医学领域有特定含义,常指在临床研究中对于不同治疗方案的利弊处于一种不确定的平衡状态,但按照要求不做额外解释)
Bioethics. 1999 Jul;13(3-4):314-26. doi: 10.1111/1467-8519.00160.
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Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 2: practical issues and specific cases.新疗法评估中的安慰剂对照试验和活性对照试验。第2部分:实际问题与具体案例。
Ann Intern Med. 2000 Sep 19;133(6):464-70. doi: 10.7326/0003-4819-133-6-200009190-00015.
6
Giving medicine a fair trial. Trials should not second guess what patients want.给予药物公正的试验机会。试验不应猜测患者的需求。
BMJ. 2000 Jun 24;320(7251):1686. doi: 10.1136/bmj.320.7251.1686.
7
Why "underpowered" trials are not necessarily unethical.为何“效能不足”的试验不一定不道德。
Lancet. 1997 Sep 13;350(9080):804-7. doi: 10.1016/s0140-6736(97)02290-3.

循证医学当前的认识论问题。

Current epistemological problems in evidence based medicine.

作者信息

Ashcroft R E

机构信息

Imperial College London, Department of Primary Health Care and General Practice, London, UK.

出版信息

J Med Ethics. 2004 Apr;30(2):131-5. doi: 10.1136/jme.2003.007039.

DOI:10.1136/jme.2003.007039
PMID:15082804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1733829/
Abstract

Evidence based medicine has been a topic of considerable controversy in medical and health care circles over its short lifetime, because of the claims made by its exponents about the criteria used to assess the evidence for or against the effectiveness of medical interventions. The central epistemological debates underpinning the debates about evidence based medicine are reviewed by this paper, and some areas are suggested where further work remains to be done. In particular, further work is needed on the theory of evidence and inference; causation and correlation; clinical judgment and collective knowledge; the structure of medical theory; and the nature of clinical effectiveness.

摘要

在其短暂的发展历程中,循证医学一直是医疗卫生领域颇具争议的话题,原因在于其倡导者对用于评估支持或反对医学干预有效性证据的标准所提出的主张。本文回顾了支撑循证医学辩论的核心认识论辩论,并指出了一些仍有待进一步开展工作的领域。特别是,在证据与推理理论、因果关系与相关性、临床判断与集体知识、医学理论结构以及临床有效性的本质等方面,仍需开展进一步的工作。