Sugisaki T, Beamer W G, Noguchi T
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
Neurochem Res. 1992 Oct;17(10):1037-40. doi: 10.1007/BF00966833.
2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the congenital goiter mouse (cog/cog) is reduced in comparison with the normal heterozygote (cog/+). The weight of the cog/cog cerebrum and cerebellum were significantly less than those of the normal controls, 89.0% less for the cerebrum, and 81.1% less for the cerebellum. However, no differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the congenital goiter mouse is restricted to the cerebrum, and is not related to arrested glial proliferation.
与正常杂合子（cog/+）相比，先天性甲状腺肿小鼠（cog/cog）大脑中的2',3'-环核苷酸3'-磷酸水解酶活性降低。cog/cog小鼠大脑和小脑的重量明显低于正常对照组，大脑重量减少89.0%，小脑重量减少81.1%。然而，在DNA和RNA含量以及RNA/DNA比值方面未观察到差异。本研究结果表明，先天性甲状腺肿小鼠的髓鞘形成减少仅限于大脑，与神经胶质细胞增殖停滞无关。
