Noguchi T, Sugisaki T, Satoh I, Kudo M
J Neurochem. 1985 Nov;45(5):1419-26. doi: 10.1111/j.1471-4159.1985.tb07208.x.
We attempted to define whether thyroid hormone can ameliorate the cerebral hypomyelination present in the congenitally hypothyroid (hyt) neonatal mouse, and to define the critical time period during early postnatal life when thyroxine (T4) is essential for myelin formation. We administered T4 to the hyt mouse by breast milk during the first 20 days of postnatal life, and through the diet during the second 20 days of postnatal life. Positive results were obtained only when hormone was given during the first 20 days of postnatal life. A distinct increase in cerebral 2',3'-cyclic nucleotide 3'-phosphohydrolase activity was noted, and brain sections stained for myelin basic protein correlated with the biochemical findings. The later administration of hormone through diet was ineffective.
我们试图确定甲状腺激素是否能改善先天性甲状腺功能减退（hyt）新生小鼠大脑中的髓鞘形成不足，并确定出生后早期甲状腺素（T4）对髓鞘形成至关重要的关键时期。我们在出生后的前20天通过母乳给hyt小鼠施用T4，并在出生后的第二个20天通过饮食施用。只有在出生后的前20天给予激素时才获得了阳性结果。观察到大脑2',3'-环核苷酸3'-磷酸水解酶活性明显增加，并且用髓鞘碱性蛋白染色的脑切片与生化结果相关。后期通过饮食给予激素无效。
