Noguchi T, Sugisaki T, Nishikawa N, Tsukada Y
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
Neurochem Res. 1988 Mar;13(3):249-52. doi: 10.1007/BF00971541.
We administered bovine growth hormone to the Little (lit), a promising model of isolated growth hormone deficiency, during the first and second 20 days after birth. Positive results were obtained only when bovine growth hormone was given during the first 20 days of postnatal life. We observed a distinct increase in cerebral weight, DNA content, and 2',3'-cyclic nucleotide 3'-phosphohydrolase activity. The latter administration of bovine growth hormone was ineffective. These data prove that growth hormone has an independent action on cerebral development, apart from the complementary or synergistic action of thyroid hormones, and that the administration of exogenous growth hormone led to increased myelinogenesis through its stimulatory effects on glial proliferation, as evidenced by the increase in cerebral DNA content.
我们在出生后的头20天和第二个20天期间，给“小个子”（lit）（一种有希望的孤立性生长激素缺乏模型）注射了牛生长激素。只有在出生后生命的头20天内给予牛生长激素时才获得了阳性结果。我们观察到脑重量、DNA含量和2'，3'-环核苷酸3'-磷酸水解酶活性明显增加。后期给予牛生长激素无效。这些数据证明，生长激素除了具有甲状腺激素的互补或协同作用外，对脑发育具有独立作用，并且外源性生长激素的给药通过其对神经胶质细胞增殖的刺激作用导致髓鞘形成增加，这一点由脑DNA含量的增加所证明。
