Holtkamp Martin, Schuchmann Sebastian, Gottschalk Stefan, Meierkord Hartmut
Neurologische Klinik, Universitätsklinikum Charité, Schumannstr. 20/21, 10117 Berlin, Germany.
J Neurol. 2004 Apr;251(4):458-63. doi: 10.1007/s00415-004-0356-9.
Neuronal consequences of recurrent single epileptic seizures have been discussed controversially for some time. Various cross-sectional magnetic resonance imaging (MRI) studies have shown a positive correlation between the severity of epilepsy and the extent of hippocampal damage. However, the open question whether recurrent epileptic seizures induce hippocampal structural pathology can be assessed only in longitudinal studies. The few recent follow-up studies have revealed conflicting results. In the current MRI study we have employed volumetry and T2 relaxometry to quantify hippocampal structural changes of patients with chronic partial epilepsies over a period of 3 years. Our main findings demonstrate that these patients who experience continuing epileptic seizures do no show any development of new pathology or any relevant deterioration of pre-existing hippocampal structural lesions. This argues against the assumption that recurrent epileptic seizures cause or increase structural hippocampal damage.
一段时间以来，复发性单次癫痫发作对神经元的影响一直存在争议。各种横断面磁共振成像（MRI）研究表明，癫痫的严重程度与海马损伤程度之间存在正相关。然而，复发性癫痫发作是否会诱发海马结构病理学这一悬而未决的问题只能在纵向研究中进行评估。最近的几项随访研究得出了相互矛盾的结果。在当前的MRI研究中，我们采用体积测量和T2弛豫测量法，对慢性部分性癫痫患者3年期间的海马结构变化进行量化。我们的主要研究结果表明，这些经历持续性癫痫发作的患者并未出现任何新的病理发展，也没有出现已存在的海马结构病变的任何相关恶化。这与复发性癫痫发作会导致或增加海马结构损伤的假设相悖。
