Bourre J M, Piciotti M
INSERM U 26, Hôpital F. Widal, Paris, France.
Neurosci Lett. 1992 Jul 6;141(1):65-8. doi: 10.1016/0304-3940(92)90335-5.
During pre- and postnatal brain development, delta-6 desaturase decreased dramatically (approx. 4-fold) up to weaning, slowly (2-fold) up to 3 months, and remained nearly constant and extremely low thereafter. In contrast, in liver, the activity increased approximately 7-fold between day 3 before birth and day 11 after birth, then decreased slightly up to weaning, and was constant up to 9 months. Subsequently, the activity decreased during aging (4-fold between 9 and 26 months). During aging, the reduced activity in liver and the very low activity in brain raise the question of the origin of polyunsaturated fatty acids participating in the physiological turnover of brain membranes.
在产前和产后大脑发育过程中，Δ-6去饱和酶在断奶前急剧下降（约4倍），到3个月时缓慢下降（2倍），此后几乎保持恒定且极低。相比之下，在肝脏中，出生前3天到出生后11天之间活性增加约7倍，然后到断奶时略有下降，直到9个月时保持恒定。随后，在衰老过程中活性下降（9至26个月之间下降4倍）。在衰老过程中，肝脏中活性降低以及大脑中活性极低，这就引发了参与脑膜生理更新的多不饱和脂肪酸来源的问题。
