利用随机及特定同胞对定位数量性状。
Mapping quantitative traits with random and with ascertained sibships.
作者信息
Peng Jie, Siegmund D
机构信息
Department of Statistics, Stanford University, Stanford, CA 94305, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 May 25;101(21):7845-50. doi: 10.1073/pnas.0401713101. Epub 2004 Apr 14.
Abstract
Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment correction are shown to be asymptotically equivalent when the number of sibships is large.
摘要
回顾了基于方差成分模型的稳健得分统计量在随机抽样家系中定位数量性状位点的应用。讨论了通过单一先证者确定的同胞对。在多元正态性的标准假设下，当同胞对数量很大时，两种建议的确定校正方法渐近等价。
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