Ozgurtas Taner, Yakut Gurer, Gulec Mahir, Serdar Muhittin, Kutluay Turker
Department of Biochemistry, Gulhane Medical School, Ankara, Turkey.
Urol Int. 2004;72(3):233-6. doi: 10.1159/000077122.
It is considered that many factors may play a role in urolithiasis. Experimental and clinical studies have shown that zinc has an inhibitory effect on urolithiasis.
In this study, urinary zinc and copper were measured in 27 healthy controls and 30 calcium oxalate stone formers.
Urinary zinc excretion was significantly higher (p < 0.001) in stone formers than healthy controls (2,575 +/- 274 and 960 +/- 80 mg/day, respectively). There was no significant difference in urinary copper excretion between healthy controls and stone formers (32.3 +/- 3.5 and 33.3 +/- 3.2 microg/day, respectively).
According to our results, the potent inhibitory effect of urinary zinc excretion on urolithiasis could be reviewed.
人们认为许多因素可能在尿路结石形成中起作用。实验和临床研究表明，锌对尿路结石有抑制作用。
在本研究中，对27名健康对照者和30名草酸钙结石患者的尿锌和铜进行了测量。
结石患者的尿锌排泄量显著高于健康对照者（分别为2575±274和960±80毫克/天，p<0.001）。健康对照者和结石患者的尿铜排泄量无显著差异（分别为32.3±3.5和33.3±3.2微克/天）。
根据我们的结果，尿锌排泄对尿路结石的强大抑制作用值得重新审视。
