Druet-Cabanac M, Boussinesq M, Dongmo L, Farnarier G, Bouteille B, Preux P M
Institute of Neuroepidemiology and Tropical Neurology EA 3174, Limoges, France.
Neuroepidemiology. 2004 May-Jun;23(3):144-9. doi: 10.1159/000075958.
A review and a meta-analysis of the available epidemiological literature for evidence of an association between onchocerciasis infection and epilepsy were carried out. We used EMBASE (1974-2002), MEDLINE (1966-2002), and PASCAL (1987-2002) databases and relevant journals and bibliographies. We limited our analysis to the epidemiological studies, where the status regarding onchocerciasis infection and epilepsy was available for each subject. Nine African studies were included. The common relative risk estimated by the random-effects model was 1.21 (95% CI 0.99-1.47; p = 0.06). The meta-analysis did not show any difference according to the onchocerciasis endemicity level and the African areas. Our results do not allow to conclude for an association between Onchocerca volvulus infection and epilepsy. However, the results are nearly significant. Further research is needed in this neglected subject, in particular for the better understanding of the neurological pathogenicity in onchocerciasis.
对现有流行病学文献进行了回顾和荟萃分析，以寻找盘尾丝虫病感染与癫痫之间存在关联的证据。我们使用了EMBASE（1974 - 2002年）、MEDLINE（1966 - 2002年）和PASCAL（1987 - 2002年）数据库以及相关期刊和参考文献。我们将分析局限于流行病学研究，即每个受试者的盘尾丝虫病感染和癫痫状况均已知的研究。纳入了9项非洲研究。随机效应模型估计的共同相对风险为1.21（95%置信区间0.99 - 1.47；p = 0.06）。荟萃分析未显示出根据盘尾丝虫病流行程度和非洲地区的任何差异。我们的结果无法得出盘尾丝虫感染与癫痫之间存在关联的结论。然而，结果几乎具有显著性。在这个被忽视的课题上需要进一步研究，特别是为了更好地理解盘尾丝虫病的神经致病性。
