Singh N Gopendro, Kapila Kusum, Mathur Sandeep, Ray Ruma, Verma Kusum
Cytopathology Laboratory, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
Acta Cytol. 2004 Mar-Apr;48(2):215-8. doi: 10.1159/000326319.
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a benign, self-limiting histiocytic proliferative disorder commonly involving the lymph nodes. Extranodal disease occurs in about 40% of cases, and the sites involved are skin, nasal cavity, paranasal sinuses, eyelids, orbit, bone and central nervous system.
A case of RDD presented as subcutaneous nodules and was diagnosed on a fine needle aspirate. The aspirate revealed numerous histiocytes with phagocytosis of lymphocytes, plasma cells and neutrophils. Surgical biopsy and immunocytochemical stain for S-100 protein confirmed the diagnosis. Later the patient developed lymphadenopathy and involvement of the nasal septum.
Extranodal RDD can be diagnosed by FNAC in conjunction with immunocytochemistry.
罗萨伊-多夫曼病（RDD），即伴巨大淋巴结病的窦性组织细胞增生症，是一种常见累及淋巴结的良性、自限性组织细胞增生性疾病。约40%的病例会出现结外病变，受累部位包括皮肤、鼻腔、鼻窦、眼睑、眼眶、骨骼和中枢神经系统。
1例RDD表现为皮下结节，通过细针穿刺抽吸确诊。抽吸物显示大量组织细胞吞噬淋巴细胞、浆细胞和中性粒细胞。手术活检及S-100蛋白免疫细胞化学染色确诊。后来患者出现淋巴结病及鼻中隔受累。
结外RDD可通过细针穿刺抽吸活检结合免疫细胞化学进行诊断。
