Goel Madhu Mati, Agarwal Padam Kumari, Agarwal Sanjeev
Department of Pathology, King George's Medical College, Lucknow, U.P., India.
Acta Cytol. 2003 Nov-Dec;47(6):1119-22. doi: 10.1159/000326661.
Solitary bone involvement without lymphadenopathy is a rare manifestation of Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML). Only 11 cases have been reported in the literature to date, all diagnosed on histology.
A 7-year-old girl had a radiolucent, lytic lesion in the shaft of the tibia clinically simulating Ewing's sarcoma. Fine needle aspiration cytology (FNAC) showed a microscopic picture typical--of SHML. There was no lymphadenopathy.
Rosai-Dorfman disease sometimes involves bone without lymphadenopathy and can be diagnosed confidently on FNAC. To the best of our knowledge, this is the 12th case report of solitary bone involvement.
孤立性骨受累且无淋巴结病是罗萨伊-多夫曼病（Rosai-Dorfman disease）或伴巨大淋巴结病的窦性组织细胞增生症（sinus histiocytosis with massive lymphadenopathy，SHML）的一种罕见表现。迄今为止，文献中仅报道了11例，均经组织学诊断。
一名7岁女孩胫骨骨干有一个透光的溶骨性病变，临床上模拟尤因肉瘤（Ewing's sarcoma）。细针穿刺细胞学检查（FNAC）显示出典型的SHML微观图像。无淋巴结病。
罗萨伊-多夫曼病有时可累及骨且无淋巴结病，通过FNAC可确诊。据我们所知，这是第12例孤立性骨受累的病例报告。
