Kurtuncu Murat, Arslan Ahmet D, Akhisaroglu Mustafa, Manev Hari, Uz Tolga
Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M/C 912, Chicago, IL 60612, USA.
Eur J Pharmacol. 2004 Apr 12;489(3):203-5. doi: 10.1016/j.ejphar.2004.03.010.
Contribution of circadian mechanisms to the psychostimulant-induced behaviors has been suggested. The pineal gland is important component of circadian mechanisms. Using pinealectomized mice and sham-operated controls, we tested the contribution of pineal gland to the rewarding effects of cocaine in conditioned place preference test. Experiments were performed both during the day and at night. Controls with intact pineal glands demonstrated significant decrease in cocaine-induced conditioned place preference at night compared to daytime, whereas pinealectomized mice did not show any diurnal differences. Circadian mechanisms regulated by the pineal gland thus appear critically involved in cocaine-induced reward.
昼夜节律机制对精神兴奋剂诱导行为的作用已被提出。松果体是昼夜节律机制的重要组成部分。我们使用松果体切除的小鼠和假手术对照组，在条件性位置偏爱试验中测试了松果体对可卡因奖赏效应的作用。实验在白天和夜间都进行。松果体完整的对照组显示，与白天相比，夜间可卡因诱导的条件性位置偏爱显著降低，而松果体切除的小鼠没有表现出任何昼夜差异。因此，由松果体调节的昼夜节律机制似乎在可卡因诱导的奖赏中起关键作用。
