Siddique Yasir Hasan, Afzal Mohammad
Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202 001, India.
Indian J Exp Biol. 2004 Apr;42(4):437-8.
Allicin, one of the sulphur compounds of garlic (Allium sativum), possesses antioxidant and thiol disulphide exchange activity and is also shown to cause a variety of activities potentially useful for human health. In this investigation, the effect of 1,5,10 and 20 microM of allicin was determined for inhibiting the rate of SCE induced by 60 microM of MMS. Cultured human lymphocytes from two female donors were used for the experiment. The levels of SCEs were lowered by allicin suggesting its antigenotoxic activity in mammalian cells in vitro.
大蒜素是大蒜（葱属植物）中的硫化合物之一，具有抗氧化和硫醇二硫键交换活性，还显示出具有多种对人体健康潜在有益的活性。在本研究中，测定了1、5、10和20微摩尔大蒜素对抑制60微摩尔甲基磺酸甲酯诱导的姐妹染色单体交换率的影响。使用来自两名女性供体的培养人淋巴细胞进行实验。大蒜素降低了姐妹染色单体交换水平，表明其在体外哺乳动物细胞中具有抗基因毒性活性。
