Siddique Yasir Hasan, Afzal Mohammad
Section of Genetics, Department of Zoology, Aligarh Muslim University, India.
J Environ Biol. 2005 Jul;26(3):547-50.
Allicin, one of the sulfur compounds especially thiosulphonates of garlic (Allium sativum), possesses antioxidant and thioldisulphide exchange activity and is also shown to cause a variety of actions potentially useful for human health. In this investigation we determined its antigenotoxic potential using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) induced by methyl methanesulphonate (MMS) as genotoxic end points both in the presence as well as absence of rat liver microsomal activation system (S9 mix) in cultured human lymphocytes. We tested the effect of 5, 10 and 20 microM of allicin on the damage exerted by 60 microM of MMS. The levels of CAs and SCEs were lowered suggesting an antigenotoxic role of allicin against genotoxic damage both in the presence as well as absence of metabolic activation.
蒜素是大蒜（葱属植物）中含硫化合物特别是硫代磺酸酯中的一种，具有抗氧化和硫醇二硫化物交换活性，并且还显示出能引发多种对人体健康潜在有益的作用。在本研究中，我们以甲基磺酸甲酯（MMS）诱导的染色体畸变（CAs）和姐妹染色单体交换（SCEs）作为遗传毒性终点，在有和没有大鼠肝微粒体激活系统（S9混合物）存在的情况下，于培养的人淋巴细胞中测定了蒜素的抗遗传毒性潜力。我们测试了5、10和20微摩尔蒜素对60微摩尔MMS所造成损伤的影响。CAs和SCEs的水平降低，表明蒜素在有和没有代谢激活的情况下，对遗传毒性损伤均具有抗遗传毒性作用。
