Wingender Edgar
Department of Bioinformatics, UKG, University of Goettingen, Goldschmidtstr. 1, D-37077 Goettingen, Germany.
In Silico Biol. 2004;4(1):55-61. Epub 2004 Mar 16.
Building an ontology of a defined knowledge domain can help to model an appropriate database structure for the relevant contents. On the other hand, having a comprehensive overview of the knowledge of a certain domain as it may be provided by corresponding databases facilitates building an appropriate ontology, or ontologies with different granularities, which may then provide many additional benefits in handling the stored and in retrieving additional information from heterogenous sources. In this communication, the first steps are reported how we may derive an ontology for the domain of "molecular regulation" from our databases TRANSFAC (transcriptional regulation), TRANSPATH (signal transduction) and CYTOMER (cellular locations).
构建一个定义明确的知识领域的本体可以帮助为相关内容建模一个合适的数据库结构。另一方面，拥有对某个领域知识的全面概述（如相应数据库可能提供的那样）有助于构建合适的本体，或具有不同粒度的本体，这在处理存储的信息以及从异构源检索额外信息时可能会带来许多额外的好处。在本交流中，报告了我们如何从我们的数据库TRANSFAC（转录调控）、TRANSPATH（信号转导）和CYTOMER（细胞定位）中为“分子调控”领域推导本体的初步步骤。
