Weisglas-Kuperus Nynke, Vreugdenhil Hestien J I, Mulder Paul G H
Division of Neonatology, Department of Pediatrics, Erasmus University and University Hospital/Sophia Children's Hospital, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands.
Toxicol Lett. 2004 Apr 1;149(1-3):281-5. doi: 10.1016/j.toxlet.2003.12.039.
Perinatal exposure to PCBs and dioxins is associated with immune changes in healthy Dutch preschool children. To examine whether such effects persist into later childhood, we here report on the immunological effects of perinatal exposure to PCBs and dioxins in 167 Dutch children at school age. A higher postnatal PCB exposure was associated with a higher prevalence of recurrent middle ear infections and a higher prenatal PCB exposure with less shortness of breath with wheeze, as assessed by parent questionnaire. Our data indicate that, at environmental levels of these man made chemicals, subtle health effects may occur.
围产期接触多氯联苯和二恶英与荷兰健康学龄前儿童的免疫变化有关。为了研究这些影响是否会持续到儿童后期，我们在此报告了167名荷兰学龄儿童围产期接触多氯联苯和二恶英的免疫学影响。通过家长问卷评估，出生后多氯联苯暴露量较高与复发性中耳感染的患病率较高相关，产前多氯联苯暴露量较高与喘息时呼吸急促较少相关。我们的数据表明，在这些人造化学物质的环境水平下，可能会出现细微的健康影响。
