Kalinin A P, Andrusenko A B, Zaretskaia Iu M, Abramov V Iu, Klinova E G, Bogatyrev O P, Donskov S I, Manishkina R P
Ter Arkh. 1992;64(2):103-8.
Ninety-seven patients suffering from Itsenko [correction of Icenko]-Cushing disease were examined. Analysis was made first of all of the clinical and laboratory signs pointing to the presence of other endocrine diseases to distinguish two groups of patients. The first group included subjects who did not manifest any concomitant diseases. The number of men and women was the same. The second group was made up of patients with associated Itsenko [correction of Icenko]-Cushing disease and other endocrine diseases. In this particular group, women were predominant. The first group patients demonstrated the predominance of the DR7 incidence, the second group that of the DR5. The method of estimating HLA associations identified is proposed. It allows distinguishing specific and nonspecific associations. In Itsenko [correction of Icenko]-Cushing disease, DR7 association is specific, whereas B8 and DR5 associations are unspecific. A specific polyendocrine autoimmune syndrome associated with Itsenko [correction of Icenko]-Cushing disease was revealed. A concept of the pathogenesis of Itsenko [correction of Icenko]-Cushing disease is advanced.
对97例患有伊钦科（纠正：伊琴科）-库欣病的患者进行了检查。首先对指向其他内分泌疾病存在的临床和实验室体征进行分析，以区分两组患者。第一组包括未表现出任何伴随疾病的受试者。男性和女性数量相同。第二组由患有相关伊钦科（纠正：伊琴科）-库欣病和其他内分泌疾病的患者组成。在这个特定组中，女性占主导。第一组患者显示DR7发生率占优势，第二组显示DR5占优势。提出了评估所确定的HLA关联的方法。它允许区分特异性和非特异性关联。在伊钦科（纠正：伊琴科）-库欣病中，DR7关联是特异性的，而B8和DR5关联是非特异性的。揭示了与伊钦科（纠正：伊琴科）-库欣病相关的特异性多内分泌自身免疫综合征。提出了伊钦科（纠正：伊琴科）-库欣病的发病机制概念。
