Kezirian Guy M, Stonecipher Karl G
Southeastern Eye Center, Greensboro, NC, USA.
J Cataract Refract Surg. 2004 Apr;30(4):804-11. doi: 10.1016/j.jcrs.2003.10.026.
To compare laser in situ keratomileusis (LASIK) results obtained with the femtosecond laser (IntraLase Corp.) to those obtained using 2 popular mechanical microkeratomes.
Private practice, Greensboro, North Carolina, USA.
This retrospective analysis compared LASIK outcomes with the femtosecond laser to those with the Carriazo-Barraquer (CB) microkeratome (Moria, Inc.) and the Hansatome microkeratome (Bausch & Lomb, Inc.). The 3 groups were matched for enrollment criteria and were operated on under similar conditions by the same surgeon.
There were 106 eyes in the IntraLase group, 126 eyes in the CB group, and 143 eyes in the Hansatome group. One day postoperatively, the uncorrected visual acuity (UCVA) results in the 3 groups were similar; at 3 months, the UCVA and the best spectacle-corrected visual acuity results were not significantly different. A manifest spheroequivalent of +/-0.50 diopter (D) was achieved in 91% of eyes in the IntraLase group, 73% of eyes in the CB group, and 74% of eyes in the Hansatome group (P<.01). IntraLase flaps were significantly thinner (P<.01) and varied less in thickness (P<.01) than flaps created with the other devices. The mean flap thickness was 114 microm +/- 14 (SD) with the IntraLase programmed for a 130 microm depth, 153 +/- 26 microm with the CB using a 130 microm plate, and 156 +/- 29 microm with the Hansatome using a 180 microm plate. Loose epithelium was encountered in 9.6% of eyes in the CB group and 7.7% of eyes in the Hansatome group but in no eye in the IntraLase group (P =.001). Surgically induced astigmatism in sphere corrections was significantly less with the IntraLase than with the other devices (P<.01).
The IntraLase demonstrated more predictable flap thickness, better astigmatic neutrality, and decreased epithelial injury than 2 popular mechanical microkeratomes.
比较使用飞秒激光（IntraLase公司）进行准分子原位角膜磨镶术（LASIK）的结果与使用两种常用机械微型角膜刀的结果。
美国北卡罗来纳州格林斯博罗的私人诊所。
这项回顾性分析将飞秒激光LASIK手术结果与卡里亚佐-巴拉克（CB）微型角膜刀（Moria公司）和汉萨特微型角膜刀（博士伦公司）的结果进行了比较。三组在入选标准上进行了匹配，并由同一位外科医生在相似条件下进行手术。
IntraLase组有106只眼，CB组有126只眼，汉萨特组有143只眼。术后一天，三组的未矫正视力（UCVA）结果相似；在3个月时，UCVA和最佳眼镜矫正视力结果无显著差异。IntraLase组91%的眼睛、CB组73%的眼睛和汉萨特组74%的眼睛实现了等效球镜度±0.50屈光度（D）（P<0.01）。与使用其他设备制作的角膜瓣相比，IntraLase角膜瓣明显更薄（P<0.01）且厚度变化更小（P<0.01）。使用130微米深度程序的IntraLase制作的角膜瓣平均厚度为114微米±14（标准差），使用130微米刀片的CB制作的角膜瓣平均厚度为153±26微米，使用180微米刀片的汉萨特制作的角膜瓣平均厚度为156±29微米。CB组9.6%的眼睛和汉萨特组7.7%的眼睛出现了上皮松解，但IntraLase组没有眼睛出现这种情况（P = 0.001）。在球镜矫正中，IntraLase引起的手术性散光明显少于其他设备（P<0.01）。
与两种常用的机械微型角膜刀相比，IntraLase表现出更可预测的角膜瓣厚度、更好的散光中和效果以及减少的上皮损伤。
