Miyazaki Katsuhiko, Miyazaki Kayoko W, Matsumoto Gen
RIKEN Brain Science Institute, Hirosawa, Wako, Saitama, Japan.
Neuroreport. 2004 Mar 22;15(4):721-6. doi: 10.1097/00001756-200403220-00030.
We recorded single units in the rat nucleus accumbens (NAcc) and medial prefrontal cortex (mPFC) to investigate activity related to reward mediation and anticipation during execution of an alternating reward task. NAcc and mPFC neurons showed increased activity differently during an interposed delay preceding reward delivery. Some NAcc neurons increased their activity specifically during the delay period before reward presentation, discriminating forthcoming food or water presentation. A subset of neurons in the mPFC similarly discriminated between food and water reward during the delay; however, about half did not discriminate reward qualities. These results show that the NAcc and the mPFC contribute differently to the organization and execution of goal-directed behavior.
我们记录了大鼠伏隔核（NAcc）和内侧前额叶皮质（mPFC）中的单个神经元，以研究在执行交替奖励任务期间与奖励介导和预期相关的活动。在奖励发放前的插入延迟期间，NAcc和mPFC神经元的活动以不同方式增加。一些NAcc神经元在奖励呈现前的延迟期内特异性地增加了它们的活动，以区分即将到来的食物或水的呈现。mPFC中的一部分神经元在延迟期间同样能够区分食物和水奖励；然而，大约一半的神经元无法区分奖励的性质。这些结果表明，NAcc和mPFC对目标导向行为的组织和执行贡献不同。
