Falconer I R, Dornbusch M, Moran G, Yeung S K
Department of Biochemistry, Microbiology and Nutrition, University of New England, Armidale NSW, Australia.
Toxicon. 1992 Jul;30(7):790-3. doi: 10.1016/0041-0101(92)90016-x.
Livestock deaths, and clinical reports of human injury, follow the consumption of toxic blue-green algae. The experiments described show that isolated intestinal enterocytes from chicks are both deformed and killed by exposure to Microcystis toxins, in a dose-dependent and time-dependent manner. The enterocytes were protected from toxicity by deoxycholate, bromosulphothalein and rifampicin. It was concluded that the gastroenteritis clinically associated with accidental Microcystis ingestion is likely to reflect enterocyte injury by Microcystis toxins, and that the therapeutic use of bile acids or transport inhibitors may be of value in treatment.
食用有毒蓝绿藻后会出现牲畜死亡以及人类受伤的临床报告。所述实验表明，雏鸡分离出的肠道肠上皮细胞暴露于微囊藻毒素后会发生变形并死亡，且呈剂量和时间依赖性。脱氧胆酸盐、溴磺酞钠和利福平可保护肠上皮细胞免受毒性影响。得出的结论是，临床上与意外摄入微囊藻相关的肠胃炎可能反映了微囊藻毒素对肠上皮细胞的损伤，并且胆汁酸或转运抑制剂的治疗用途可能对治疗有价值。
