Klemola T, Seppälä I, Savilahti E
Children's Hospital, University of Helsinki, Finland.
J Clin Lab Immunol. 1988 Jan;25(1):29-34.
We measured IgG subclass levels by radial immunodiffusion with polyclonal antisera in 60 patients with IgA deficiency. The low IgA levels were measured by a sensitive and specific enzymoimmunometric method. None of the patients had complete deficiency of IgG2, but 4 patients had serum levels of IgG2 and 4 of IgG3 below the range for controls. Elevated levels of IgG1 were found in patients with juvenile rheumatoid arthritis and coeliac disease. None of the patients with coeliac disease or juvenile rheumatoid arthritis had low IgG2 or IgG3 levels. The levels of IgG4 were highly variable but patients with coeliac disease had particularly high values. The severity of IgA deficiency did not correlate with the level of serum IgG2.
我们采用放射免疫扩散法，使用多克隆抗血清对60例IgA缺乏患者的IgG亚类水平进行了检测。采用灵敏且特异的酶免疫分析法测定低IgA水平。所有患者均无IgG2完全缺乏的情况，但有4例患者的IgG2血清水平以及4例患者的IgG3血清水平低于对照组范围。幼年类风湿关节炎和乳糜泻患者中发现IgG1水平升高。乳糜泻或幼年类风湿关节炎患者均无低IgG2或IgG3水平。IgG4水平变化很大，但乳糜泻患者的IgG4水平尤其高。IgA缺乏的严重程度与血清IgG2水平无关。
