List Marcy A, Bilir S Pinar
University of Chicago Cancer Research Center, Chicago, IL 60637, USA.
Semin Radiat Oncol. 2004 Apr;14(2):178-89. doi: 10.1053/j.semradonc.2003.12.008.
For advanced head and neck cancer (HNC) patients, the effects of disease and the side effects of aggressive treatments have the potential to severely affect function and quality of life. More recent treatment strategies offer patients many options and have increased rates of locoregional control. However, they have not eliminated either acute treatment side effects or the spectrum of negative late sequelae, such as eating and speech dysfunction, residual pain, and troublesome dryness of the mouth. Understanding this broad spectrum of side effects and how patients experience them as well as the functional and quality of life implications is important to treatment evaluation and patient decision making. The heterogeneity of HNC patients (in terms of tumor site), the diversity of surgical techniques and chemoradiotherapy regimens, together with individual patient differences in response to these variables, make it particularly difficult to describe precise outcomes attached to various treatment options. However, in the context of this caveat, there are increasing data documenting the impact of various treatment modalities on physical, functional, and QOL outcomes. This article presents some of these data with a focus on the performance and functional results of radiation therapy, surgery, or concomitant chemoradiation therapy.
对于晚期头颈癌（HNC）患者，疾病的影响以及积极治疗的副作用有可能严重影响其功能和生活质量。最近的治疗策略为患者提供了多种选择，并提高了局部区域控制率。然而，它们既没有消除急性治疗副作用，也没有消除一系列负面的晚期后遗症，如进食和言语功能障碍、残留疼痛以及令人烦恼的口干。了解这些广泛的副作用、患者如何体验这些副作用以及其对功能和生活质量的影响，对于治疗评估和患者决策至关重要。头颈癌患者的异质性（在肿瘤部位方面）、手术技术和放化疗方案的多样性，以及患者对这些变量反应的个体差异，使得描述各种治疗选择所带来的确切结果变得尤为困难。然而，在这一前提下，越来越多的数据记录了各种治疗方式对身体、功能和生活质量结果的影响。本文呈现了其中一些数据，重点关注放射治疗、手术或同步放化疗的性能和功能结果。
