Blank Martin, Goodman Reba
Department of Physiology, Columbia University, New York, New York 10032, USA.
J Cell Physiol. 2004 Jun;199(3):359-63. doi: 10.1002/jcp.20004.
Low frequency electromagnetic (EM) fields induce gene expression, and recent insights into physical interactions of EM fields with model systems suggest a mechanism that could initiate this process. The consistently low thresholds at which EM fields stimulate biological processes indicate that they require little energy. Since it has been shown that such weak fields accelerate electron transfer reactions, they could stimulate transcription by interacting with electrons in DNA to destabilize the H-bonds holding the two DNA strands together. Such a mechanism is consistent with the low electron affinity of the bases in previously identified electromagnetic response elements (EMREs) needed for EM field interaction with DNA. It is also in line with both endogenous and in vitro stimulation of biosynthesis by electric fields. The frequency response of several EM sensitive biological systems suggests that EM fields require repetition and are most effective at frequencies that coincide with natural rhythms of the processes affected.
低频电磁场可诱导基因表达，最近对电磁场与模型系统物理相互作用的深入了解表明了一种可能启动这一过程的机制。电磁场刺激生物过程的阈值一直很低，这表明它们所需能量很少。由于已经表明这种弱场会加速电子转移反应，它们可能通过与DNA中的电子相互作用来破坏将两条DNA链维系在一起的氢键，从而刺激转录。这样一种机制与先前确定的电磁场与DNA相互作用所需的电磁响应元件（EMREs）中碱基的低电子亲和力相一致。这也与电场对生物合成的内源性和体外刺激相符。几个对电磁场敏感的生物系统的频率响应表明，电磁场需要重复作用，并且在与受影响过程的自然节律一致的频率下最为有效。
