Deshmukh Pravin Suryakantrao, Megha Kanu, Banerjee Basu Dev, Ahmed Rafat Sultana, Chandna Sudhir, Abegaonkar Mahesh Pandurang, Tripathi Ashok Kumar
Department of Biochemistry, Environmental Biochemistry and Molecular Biology Laboratory, University College of Medical Sciences and G.T.B. Hospital (University of Delhi), Dilshad Garden, New Delhi, India.
Toxicol Int. 2013 Jan;20(1):19-24. doi: 10.4103/0971-6580.111549.
Non-ionizing radiofrequency radiation has been increasingly used in industry, commerce, medicine and especially in mobile phone technology and has become a matter of serious concern in present time.
The present study was designed to investigate the possible deoxyribonucleic acid (DNA) damaging effects of low-level microwave radiation in brain of Fischer rats.
Experiments were performed on male Fischer rats exposed to microwave radiation for 30 days at three different frequencies: 900, 1800 and 2450 MHz. Animals were divided into 4 groups: Group I (Sham exposed): Animals not exposed to microwave radiation but kept under same conditions as that of other groups, Group II: Animals exposed to microwave radiation at frequency 900 MHz at specific absorption rate (SAR) 5.953 × 10(-4) W/kg, Group III: Animals exposed to 1800 MHz at SAR 5.835 × 10(-4) W/kg and Group IV: Animals exposed to 2450 MHz at SAR 6.672 × 10(-4) W/kg. At the end of the exposure period animals were sacrificed immediately and DNA damage in brain tissue was assessed using alkaline comet assay.
In the present study, we demonstrated DNA damaging effects of low level microwave radiation in brain.
We concluded that low SAR microwave radiation exposure at these frequencies may induce DNA strand breaks in brain tissue.
非电离射频辐射在工业、商业、医学领域，尤其是在移动电话技术中使用日益广泛，目前已成为一个备受关注的问题。
本研究旨在调查低水平微波辐射对Fischer大鼠脑部可能产生的脱氧核糖核酸（DNA）损伤作用。
对雄性Fischer大鼠进行实验，使其在900、1800和2450 MHz这三种不同频率下暴露于微波辐射30天。动物被分为4组：第一组（假暴露组）：未暴露于微波辐射但饲养条件与其他组相同的动物；第二组：在比吸收率（SAR）为5.953×10⁻⁴W/kg的情况下暴露于900 MHz微波辐射的动物；第三组：在SAR为5.835×10⁻⁴W/kg的情况下暴露于1800 MHz的动物；第四组：在SAR为6.672×10⁻⁴W/kg的情况下暴露于2450 MHz的动物。在暴露期结束时，立即处死动物，并使用碱性彗星试验评估脑组织中的DNA损伤。
在本研究中，我们证明了低水平微波辐射对脑部具有DNA损伤作用。
我们得出结论，在这些频率下低SAR微波辐射暴露可能会诱导脑组织中的DNA链断裂。
