Fan Guangqin, Yuan Zhaokang, Zheng Huilie, Liu Zhigang
School of Public Health, Jiangxi Medical College, Nanchang 330006, China.
Wei Sheng Yan Jiu. 2004 Jan;33(1):23-8.
To study the effects of environmental exposure to rare earth elements (REEs) on health in children.
The level of physical growth and development, function of immune system, intelligence were chosen as the health-response indexes of children. Indicators for physical growth and development were measured. IgA, IgG, IgM and complement C3, C4 in blood serum were determined with turbidimeter measure, IgE were determined by chemiluminescence immunoassay (CLIA), lymphocyle subset CD3, CD4, CD8, CD4/CD8 and NK were determined by flowcytometry. Intelligence quotient (IQ) were examined with Drawing A Man Test in the children aged 7-10 years randomly sampled in the area containing rare earth (RE) ore and the control area in Xunwucounty, Jiangxi. Blood REEs were determined by inductively coupled plasma source mass pectrometry (ICP-MS).
All 15 kinds of REEs were detected in each sample, the quantity of blood REEs of the children were lower in exposure group than in control group and in the rare earth area [(2.10 +/- 0.88)ng/g] was 1.73 times as that of the children in the control area [(1.26 +/- 1.35) ng/g]. The difference is significant (P < 0.01). The humoral immunity would be changed in the body of the children exposed to REEs, the quantity of IgM was lower in exposure group than in control group. The measuring result of T lymph subgroup of the children indicates: CD3, CD4, CD4/CD8 changed a lot. The percent of CD3, CD8 were significantly lower and CD4/CD8 was significantly higher in exposure group than in control group. The score of IQ was lower significantly in the exposure group than in the control. The percentage of high IQ decreased, the percentage of low IQ increased. Multiple regression analysis showed the variable of blood REEs in exposure to REEs group or those in the control group were introduced into the Vital capacity, blood pressure and IgM regression model. The distance from home to the RE area and either RE put in home influenced the score of children's IQ.
The children aged 7-10 years in RE ore area may have higher REEs burden in the body, and exposure to REEs could have adverse influences in children.
研究环境暴露于稀土元素（REEs）对儿童健康的影响。
选取儿童身体生长发育水平、免疫系统功能、智力作为健康反应指标。测量身体生长发育指标。用比浊法测定血清中IgA、IgG、IgM和补体C3、C4，用化学发光免疫分析法（CLIA）测定IgE，用流式细胞术测定淋巴细胞亚群CD3、CD4、CD8、CD4/CD8和NK。对江西省寻乌县稀土矿所在地区和对照地区随机抽取的7 - 10岁儿童用画人测验法检测智商（IQ）。用电感耦合等离子体质谱法（ICP - MS）测定血液中的稀土元素。
每个样本均检测到全部15种稀土元素，暴露组儿童血液中稀土元素含量低于对照组，稀土矿区儿童血液中稀土元素含量[（2.10±0.88）ng/g]是对照地区儿童[（1.26±1.35）ng/g]的1.73倍。差异有统计学意义（P < 0.01）。暴露于稀土元素的儿童体内体液免疫会发生改变，暴露组IgM含量低于对照组。儿童T淋巴细胞亚群检测结果显示：CD3、CD4、CD4/CD8变化较大。暴露组CD3、CD8百分比显著低于对照组，CD4/CD8显著高于对照组。暴露组IQ得分显著低于对照组。高智商百分比下降，低智商百分比上升。多元回归分析显示，将暴露于稀土元素组或对照组血液中稀土元素变量引入肺活量、血压和IgM回归模型。家到稀土矿区的距离以及家中是否放置稀土影响儿童IQ得分。
稀土矿区7 - 10岁儿童体内可能有较高的稀土元素负荷，暴露于稀土元素可能对儿童产生不良影响。
