Masui Kentaro, Ikegami Haruka, Mori Atsunori
Chemical Resources Laboratory, Tokyo Institute of Technology, Yokohama, Japan.
J Am Chem Soc. 2004 Apr 28;126(16):5074-5. doi: 10.1021/ja031855p.
Palladium-catalyzed C-H homocoupling of thiophene derivatives takes place in the presence of silver(I) fluoride or acetate. A variety of bithiophenes are obtained in good to excellent yields. In particular, the reaction of 2-bromothiophene proceeds at room temperature to afford 5,5'-dibromo-2,2'-bithiophene, where the bromine atom is completely intact in the palladium-catalyzed reaction. XRD analysis reveals that silver fluoride is reduced to silver(0) during the reaction.
钯催化噻吩衍生物的C-H均偶联反应在氟化银(I)或乙酸银存在下进行。可得到各种联噻吩，产率良好至优异。特别地，2-溴噻吩的反应在室温下进行，得到5,5'-二溴-2,2'-联噻吩，其中溴原子在钯催化反应中完全保持不变。X射线衍射分析表明，反应过程中氟化银被还原为银(0)。
