Varshney Manoj, Morey Timothy E, Shah Dinesh O, Flint Jason A, Moudgil Brij M, Seubert Christoph N, Dennis Donn M
Engineering Research Center for Particle Science and Technology, University of Florida, Gainesville, 32610 USA.
J Am Chem Soc. 2004 Apr 28;126(16):5108-12. doi: 10.1021/ja0394479.
We hypothesized that custom-designed microemulsions would effectively scavenge compounds from bulk media. Pluronic-based oil-in-water microemulsions were synthesized that efficiently reduced the free concentration of the local anesthetic bupivacaine in 0.9% NaCl. Both the molecular nature and concentration of the constituents in the microemulsions significantly affected extraction efficiencies. Pluronic F127-based microemulsions extracted bupivacaine more efficiently than microemulsions synthesized using other Pluronic surfactants (L44, L62, L64, F77, F87, F88, P104). Extraction was markedly increased by addition of fatty acid sodium salts due to greater oil/water interface area, increased columbic interaction between bupivacaine and fatty acids sodium salt, and greater surface activity. These data suggest that oil-in-water microemulsions may be an effective agent to treat cardiotoxicity caused by bupivacaine or other lipophilic drugs.
我们推测定制设计的微乳液能够有效地从大量介质中清除化合物。合成了基于普朗尼克的水包油型微乳液，其能有效降低0.9%氯化钠中局部麻醉剂布比卡因的游离浓度。微乳液中成分的分子性质和浓度均显著影响萃取效率。基于普朗尼克F127的微乳液比使用其他普朗尼克表面活性剂（L44、L62、L64、F77、F87、F88、P104）合成的微乳液更有效地萃取布比卡因。由于油/水界面面积增大、布比卡因与脂肪酸钠盐之间的静电相互作用增强以及表面活性提高，添加脂肪酸钠盐后萃取显著增加。这些数据表明，水包油型微乳液可能是治疗布比卡因或其他亲脂性药物引起的心脏毒性的有效药物。
